Version 5.4
Homo sapiens Gene: CES4A
Summary
InnateDB Gene IDBG-35885.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CES4A
Gene Name carboxylesterase 4A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172824
Encoded Proteins
IDBP-597796
carboxylesterase 4A
IDBP-601219
carboxylesterase 4A
IDBP-602271
carboxylesterase 4A
IDBP-583427
carboxylesterase 4A
IDBP-598744
carboxylesterase 4A
IDBP-745437
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES6, encodes a secreted enzyme, and may play a role in the detoxification of drugs and xenobiotics in neural and other tissues of the body and in the cerebrospinal fluid. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:66988589-67009758
Strand Forward strand
Band q22.1
Transcripts
ENST00000397205
ENST00000540947 ENSP00000444052
ENST00000538199 ENSP00000441103
ENST00000535543 ENSP00000444182
ENST00000540579 ENSP00000441907
ENST00000535696 ENSP00000441644
ENST00000543561
ENST00000544986
ENST00000535948
ENST00000544478
ENST00000567587 ENSP00000458664
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000060560
View Gene Order
ENSBTAG00000038325
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.346947
RefSeq NM_001190201 NM_001190202 NM_173815 XM_005255897 XM_006721178
HUGO
OMIM
CCDS CCDS42174 CCDS54024 CCDS54025
HPRD 07116
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca