InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mb21d1

Summary

InnateDB Gene

IDBG-186803.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mb21d1

Gene Name

Mab-21 domain containing 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032344

Encoded Proteins

IDBP-186807

RIKEN cDNA E330016A19 gene

IDBP-186809

RIKEN cDNA E330016A19 gene

IDBP-538765

RIKEN cDNA E330016A19 gene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25642965

Aberrant mitochondrial DNA (mtDNA) packaging promotes escape of mtDNA into the cytosol, where it engages the DNA sensor Mb21d1 and promotes Tmem173-Irf3-dependent signalling to elevate IFN-stimulated gene expression, potentiate type I IFN responses and confer broad viral resistance.

PMID 26944200

The cationic polymer and vaccine adjuvant chitosan can engage the Tmem173/Mb21d1 (STING/cGAS) pathway to trigger innate and adaptive immune responses.

InnateDB Annotation from Orthologs

Summary

PMID 23707061

[Homo sapiens] MB21D1 (cGAS) is a cytosolic DNA sensor and is required for the induction of the interferon response.

PMID 24284630

[Homo sapiens] Cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS, also known as MB21D1) is pivotal in protecting the host from both DNA and RNA viruses

PMID 24269171

[Homo sapiens] Cytosolic DNA sensor cGAS (MB21D1) is essential in human dentritic cells for innate sensing of HIV-1 and HIV-2.

PMID 25425575

[Homo sapiens] Cytosolic RNA:DNA hybrids are sensed by the MB21D1-TMEM173 (cGAS-STING) pathway of the innate immune system.

PMID 25831530

[Homo sapiens] IFI16 and MB21D1 interact and cooperate during herpes simplex virus infection to initiate innate signalling.

PMID 26046437

[Homo sapiens] PQBP1 directly binds to reverse-transcribed HIV-1 DNA and interacts with MB21D1 to initiate an IRF3-dependent innate response.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164430:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:78430526-78443237

Strand

Reverse strand

Band

Transcripts

ENSMUST00000070742	ENSMUSP00000063331
ENSMUST00000034898	ENSMUSP00000034898
ENSMUST00000127190	ENSMUSP00000114277

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0046872	metal ion binding
GO:0061501	cyclic-GMP-AMP synthase activity

Biological Process

GO:0002218	activation of innate immune response
GO:0002230	positive regulation of defense response to virus by host
GO:0009190	cyclic nucleotide biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus
GO:0071360	cellular response to exogenous dsRNA