InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MB21D1

Summary

InnateDB Gene

IDBG-629558.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MB21D1

Gene Name

Uncharacterized protein

Synonyms

cGAS

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000892

Encoded Proteins

IDBP-680968

Mab-21 domain containing 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23707061

[Homo sapiens] MB21D1 (cGAS) is a cytosolic DNA sensor and is required for the induction of the interferon response.

PMID 24284630

[Homo sapiens] Cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS, also known as MB21D1) is pivotal in protecting the host from both DNA and RNA viruses

PMID 24269171

[Homo sapiens] Cytosolic DNA sensor cGAS (MB21D1) is essential in human dentritic cells for innate sensing of HIV-1 and HIV-2.

PMID 25425575

[Homo sapiens] Cytosolic RNA:DNA hybrids are sensed by the MB21D1-TMEM173 (cGAS-STING) pathway of the innate immune system.

PMID 25831530

[Homo sapiens] IFI16 and MB21D1 interact and cooperate during herpes simplex virus infection to initiate innate signalling.

PMID 26046437

[Homo sapiens] PQBP1 directly binds to reverse-transcribed HIV-1 DNA and interacts with MB21D1 to initiate an IRF3-dependent innate response.

PMID 25642965

[Mus musculus] Aberrant mitochondrial DNA (mtDNA) packaging promotes escape of mtDNA into the cytosol, where it engages the DNA sensor Mb21d1 and promotes Tmem173-Irf3-dependent signalling to elevate IFN-stimulated gene expression, potentiate type I IFN responses and confer broad viral resistance.

PMID 26944200

[Mus musculus] The cationic polymer and vaccine adjuvant chitosan can engage the Tmem173/Mb21d1 (STING/cGAS) pathway to trigger innate and adaptive immune responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164430:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:13154613-13177012

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000001184

ENSBTAP00000001184

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016740	transferase activity
GO:0016779	nucleotidyltransferase activity
GO:0046872	metal ion binding
GO:0061501	cyclic-GMP-AMP synthase activity

Biological Process

GO:0002218	activation of innate immune response
GO:0002230	positive regulation of defense response to virus by host
GO:0002376	immune system process
GO:0009190	cyclic nucleotide biosynthetic process
GO:0045087	innate immune response
GO:0051607	defense response to virus
GO:0071360	cellular response to exogenous dsRNA