Version 5.4
Mus musculus Gene: Ldha
Summary
InnateDB Gene IDBG-186954.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ldha
Gene Name lactate dehydrogenase A
Synonyms l7R2; Ldh1; Ldhm
Species Mus musculus
Ensembl Gene ENSMUSG00000063229
Encoded Proteins
IDBP-172409
lactate dehydrogenase A
IDBP-186956
lactate dehydrogenase A
IDBP-266230
lactate dehydrogenase A
IDBP-536999
lactate dehydrogenase A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to hemolytic anemia and early postimplantation death in mice. Two transcript variants encoding different isoforms have been found for this gene. The mouse genome contains multiple pseudogenes of this gene. [provided by RefSeq, Sep 2009]
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to hemolytic anemia and early postimplantation death in mice. Multiple transcript variants encoding different isoforms have been found for this gene. The mouse genome contains multiple pseudogenes of this gene. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:46841475-46855627
Strand Forward strand
Band B3
Transcripts
ENSMUST00000092621 ENSMUSP00000097661
ENSMUST00000048209 ENSMUSP00000036386
ENSMUST00000005051 ENSMUSP00000103267
ENSMUST00000147535 ENSMUSP00000123356
ENSMUST00000125862
ENSMUST00000124696
ENSMUST00000133062
ENSMUST00000132157
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 20 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006096 glycolytic process
GO:0021762 substantia nigra development
GO:0031668 cellular response to extracellular stimulus
GO:0044262 cellular carbohydrate metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
GO:0035686 sperm fibrous sheath
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134333
View Gene Order
ENSBTAG00000008683
Not yet available
Pathways
NETPATH
REACTOME
REACT_189162
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_188937
Metabolism pathway
REACT_253080
Pyruvate metabolism pathway
REACT_241308
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
KEGG
mmu00010
Glycolysis / Gluconeogenesis pathway
mmu00640
Propanoate metabolism pathway
mmu00620
Pyruvate metabolism pathway
mmu00270
Cysteine and methionine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
REACT_2071
Pyruvate metabolism pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
REACT_215469
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_226374
Pyruvate metabolism pathway
REACT_219139
Metabolism pathway
REACT_220485
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00620
Pyruvate metabolism pathway
hsa00640
Propanoate metabolism pathway
hsa00270
Cysteine and methionine metabolism pathway
INOH
INOH website
Propanoate metabolism pathway
INOH website
Glycolysis Gluconeogenesis pathway
INOH website
Pyruvate metabolism pathway
INOH website
Methionine Cysteine metabolism pathway
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt P06151
TrEMBL D3YZQ9 D3Z736 G5E8N5 Q3UIC3 Q564E2
UniProt Splice Variant
Entrez Gene 16828
UniGene Mm.29324 Mm.343055 Mm.437567 Mm.441359
RefSeq NM_001136069 NM_010699
OMIM
CCDS CCDS21289 CCDS52255
HPRD
IMGT
MGI ID MGI:96759
MGI Symbol Ldha
EMBL AC090123 AK089929 AK146980 AK150156 AK167789 AK168920 AK170386 BC094019 BC094428 CH466603 M17516 U13687 X02520 X02521 X02522 X02523 X02524 X02525 X02526 X03753 Y00309
GenPept AAA21466 AAA39424 AAH94019 AAH94428 BAC41000 BAE27583 BAE29347 BAE39819 BAE40733 BAE41760 CAA26360 CAA27387 CAA68410 EDL22946 EDL22947
RNA Seq Atlas 16828

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca