InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: LDHA

Summary

InnateDB Gene

IDBG-642426.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LDHA

Gene Name

L-lactate dehydrogenase A chain

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008683

Encoded Proteins

IDBP-694881

L-lactate dehydrogenase A chain

IDBP-694882

L-lactate dehydrogenase A chain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134333:
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:26543861-26554318

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000011447	ENSBTAP00000011447
ENSBTAT00000056276	ENSBTAP00000047729

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004459	L-lactate dehydrogenase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006096	glycolytic process
GO:0021762	substantia nigra development
GO:0031668	cellular response to extracellular stimulus
GO:0044262	cellular carbohydrate metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0016020	membrane
GO:0035686	sperm fibrous sheath
GO:0070062	extracellular vesicular exosome