InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Eef1a1

Summary

InnateDB Gene

IDBG-186957.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eef1a1

Gene Name

eukaryotic translation elongation factor 1 alpha 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037742

Encoded Proteins

IDBP-186959

eukaryotic translation elongation factor 1 alpha 1

IDBP-534269

eukaryotic translation elongation factor 1 alpha 1

IDBP-536260

eukaryotic translation elongation factor 1 alpha 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156508:
This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]
This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66%% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:78478449-78489151

Strand

Reverse strand

Band

Transcripts

ENSMUST00000042235	ENSMUSP00000042457
ENSMUST00000129380
ENSMUST00000143570
ENSMUST00000144523
ENSMUST00000150960
ENSMUST00000154207	ENSMUSP00000120438
ENSMUST00000126614
ENSMUST00000156988	ENSMUSP00000116821

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 252 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	252 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003746	translation elongation factor activity
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019901	protein kinase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006414	translational elongation
GO:0071364	cellular response to epidermal growth factor stimulus

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome