InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EEF1A1

Summary

InnateDB Gene

IDBG-92423.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EEF1A1

Gene Name

eukaryotic translation elongation factor 1 alpha 1

Synonyms

CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1; EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1

Species

Homo sapiens

Ensembl Gene

ENSG00000156508

Encoded Proteins

IDBP-92425

eukaryotic translation elongation factor 1 alpha 1

IDBP-92429

eukaryotic translation elongation factor 1 alpha 1

IDBP-92431

eukaryotic translation elongation factor 1 alpha 1

IDBP-92435

eukaryotic translation elongation factor 1 alpha 1

IDBP-383910

eukaryotic translation elongation factor 1 alpha 1

IDBP-807148

eukaryotic translation elongation factor 1 alpha 1

IDBP-807164

eukaryotic translation elongation factor 1 alpha 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]
This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66%% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:73515750-73523797

Strand

Reverse strand

Band

q13

Transcripts

ENST00000316292	ENSP00000339063
ENST00000309268	ENSP00000339053
ENST00000331523	ENSP00000330054
ENST00000356303	ENSP00000348651
ENST00000455918	ENSP00000392366
ENST00000491404
ENST00000490569
ENST00000495333
ENST00000488500
ENST00000610520	ENSP00000479609
ENST00000615060	ENSP00000479055

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 370 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	370 [view]
Protein-Protein	367 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003746	translation elongation factor activity
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019901	protein kinase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006412	translation
GO:0006414	translational elongation
GO:0010467	gene expression
GO:0044267	cellular protein metabolic process
GO:0071364	cellular response to epidermal growth factor stimulus

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005853	eukaryotic translation elongation factor 1 complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome