Version 5.4
Mus musculus Gene: Gfi1
Summary
InnateDB Gene IDBG-187244.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gfi1
Gene Name growth factor independent 1
Synonyms AW495828; Gfi-1; Pal-1; Pal1
Species Mus musculus
Ensembl Gene ENSMUSG00000029275
Encoded Proteins
IDBP-724958
IDBP-724841
IDBP-724865
IDBP-725009
IDBP-724964
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162676:
This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:107716657-107726036
Strand Reverse strand
Band F
Transcripts
ENSMUST00000031205 ENSMUSP00000135884
ENSMUST00000065478 ENSMUSP00000135039
ENSMUST00000159164 ENSMUSP00000137229
ENSMUST00000159263 ENSMUSP00000135880
ENSMUST00000165344 ENSMUSP00000134960
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 17 [view]
Protein-DNA 23 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0007638 mechanosensory behavior
GO:0009996 negative regulation of cell fate specification
GO:0010956 negative regulation of calcidiol 1-monooxygenase activity
GO:0010977 negative regulation of neuron projection development
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0034121 regulation of toll-like receptor signaling pathway
GO:0042472 inner ear morphogenesis
GO:0042491 auditory receptor cell differentiation
GO:0042660 positive regulation of cell fate specification
GO:0045165 cell fate commitment
GO:0045892 negative regulation of transcription, DNA-templated
GO:0070105 positive regulation of interleukin-6-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005634 nucleus
GO:0016363 nuclear matrix
GO:0016604 nuclear body
GO:0017053 transcriptional repressor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000162676
View Gene Order
ENSBTAG00000016723
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
myc_represspathway
Validated targets of C-MYC transcriptional repression
Cross-References
SwissProt
TrEMBL A1L3P3 H3BJM0 H3BLQ9
UniProt Splice Variant
Entrez Gene 14581
UniGene Mm.2078 Mm.402241 Mm.453139
RefSeq NM_001267621 NM_010278 XM_006534791 XM_006534793 XM_006534794
OMIM
CCDS CCDS59680 CCDS57371
HPRD
IMGT
MGI ID MGI:103170
MGI Symbol Gfi1
EMBL AC138666 BC130219
GenPept AAI30220
RNA Seq Atlas 14581

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca