InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GFI1

Summary

InnateDB Gene

IDBG-636580.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GFI1

Gene Name

zinc finger protein Gfi-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016723

Encoded Proteins

IDBP-688508

growth factor independent 1 transcription repressor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162676:
This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:51104164-51112405

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022231

ENSBTAP00000022231

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.

Predicted by orthology
Total	49 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0007638	mechanosensory behavior
GO:0009996	negative regulation of cell fate specification
GO:0010956	negative regulation of calcidiol 1-monooxygenase activity
GO:0010977	negative regulation of neuron projection development
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0034121	regulation of toll-like receptor signaling pathway
GO:0042472	inner ear morphogenesis
GO:0042491	auditory receptor cell differentiation
GO:0042660	positive regulation of cell fate specification
GO:0045165	cell fate commitment
GO:0045892	negative regulation of transcription, DNA-templated
GO:0070105	positive regulation of interleukin-6-mediated signaling pathway
GO:0071222	cellular response to lipopolysaccharide

Cellular Component

GO:0005634	nucleus
GO:0016363	nuclear matrix
GO:0016604	nuclear body
GO:0017053	transcriptional repressor complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000162676

View Gene Order

ENSMUSG00000029275

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

myc_represspathway

Validated targets of C-MYC transcriptional repression

Cross-References

SwissProt

TrEMBL

F1MPJ9

UniProt Splice Variant

Entrez Gene

100139952

UniGene

Bt.28572

RefSeq

NM_001191312 XM_005204252

HUGO

HGNC:4237

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02007904

GenPept

RNA Seq Atlas

100139952