Version 5.4
Mus musculus Gene: Mbnl2
Summary
InnateDB Gene IDBG-187361.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mbnl2
Gene Name muscleblind-like 2
Synonyms 1110002M11Rik; AI047808; AI837313; AI849185; AL118326; MBLL; mKIAA4072; R75232
Species Mus musculus
Ensembl Gene ENSMUSG00000022139
Encoded Proteins
IDBP-187365
muscleblind-like 2
IDBP-620590
muscleblind-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139793:
This gene is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. This gene encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:120275669-120431697
Strand Forward strand
Band E4
Transcripts
ENSMUST00000088419 ENSMUSP00000085763
ENSMUST00000167459 ENSMUSP00000126186
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0043484 regulation of RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000139793
View Gene Order
ENSBTAG00000018313
Not yet available
Cross-References
SwissProt Q8C181
TrEMBL
UniProt Splice Variant
Entrez Gene 105559
UniGene Mm.421490 Mm.490621
RefSeq NM_175341 NM_207515 XM_006518374
OMIM
CCDS CCDS49567 CCDS49568
HPRD
IMGT
MGI ID MGI:2145597
MGI Symbol Mbnl2
EMBL AK028797 AK085709 AK151913 AK151926 AK151957 AK159213 AK164372 AK167479 AK220470 BC075665
GenPept AAH75665 BAC26125 BAC39515 BAD90497 BAE30793 BAE30803 BAE30829 BAE34902 BAE37762 BAE39560
RNA Seq Atlas 105559

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca