Version 5.4
Bos taurus Gene: MBNL2
Summary
InnateDB Gene IDBG-632973.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MBNL2
Gene Name muscleblind-like protein 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018313
Encoded Proteins
IDBP-684638
muscleblind-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139793:
This gene is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. This gene encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:78283460-78445751
Strand Forward strand
Band
Transcripts
ENSBTAT00000030532 ENSBTAP00000030511
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0043484 regulation of RNA splicing
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000139793
View Gene Order
ENSMUSG00000022139
View Gene Order
Cross-References
SwissProt
TrEMBL A5PKK4
UniProt Splice Variant
Entrez Gene 527679
UniGene Bt.102795 Bt.11788 Bt.66566
RefSeq NM_001099710
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142520 DAAA02034610 DAAA02034611 DAAA02034612 DAAA02034613 DAAA02034614 DAAA02034615 DAAA02034616 DAAA02034617
GenPept AAI42521
RNA Seq Atlas 527679

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca