InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ipo5

Summary

InnateDB Gene

IDBG-187518.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ipo5

Gene Name

importin 5

Synonyms

1110011C18Rik; 5730478E03Rik; AA409333; C76941; IMB3; Kpnb3; Ranbp5

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030662

Encoded Proteins

IDBP-187520

importin 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065150:
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:120911194-120948042

Strand

Forward strand

Band

Transcripts

ENSMUST00000032898

ENSMUSP00000032898

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008536	Ran GTPase binding
GO:0008565	protein transporter activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006607	NLS-bearing protein import into nucleus
GO:0006610	ribosomal protein import into nucleus
GO:0006886	intracellular protein transport
GO:0042307	positive regulation of protein import into nucleus
GO:0071230	cellular response to amino acid stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0031965	nuclear membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000065150

View Gene Order

ENSBTAG00000039374

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_9434

vRNP Assembly pathway

REACT_6167

Influenza Infection pathway

REACT_6152

Influenza Viral RNA Transcription and Replication pathway

REACT_6145

Influenza Life Cycle pathway

REACT_116125

Disease pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q8BKC5

TrEMBL

Q7TN23

UniProt Splice Variant

Entrez Gene

70572

UniGene

Mm.221452 Mm.456887 Mm.472208

RefSeq

NM_023579 XM_006519540

OMIM

CCDS

CCDS37014

HPRD

IMGT

MGI ID

MGI:1917822

MGI Symbol

Ipo5

EMBL

AF294327 AK053681 AK169664 BC051433 BC052392 BC054814

GenPept

AAG45965 AAH51433 AAH52392 AAH54814 BAC35471 BAE41286

RNA Seq Atlas

70572