Version 5.4
Homo sapiens Gene: IPO5
Summary
InnateDB Gene IDBG-44066.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IPO5
Gene Name importin 5
Synonyms IMB3; imp5; KPNB3; Pse1; RANBP5
Species Homo sapiens
Ensembl Gene ENSG00000065150
Encoded Proteins
IDBP-44068
importin 5
IDBP-44070
importin 5
IDBP-294027
importin 5
IDBP-372135
importin 5
IDBP-482526
importin 5
IDBP-473779
importin 5
IDBP-481942
importin 5
IDBP-480683
importin 5
IDBP-484896
importin 5
IDBP-477207
importin 5
IDBP-485426
importin 5
IDBP-485425
importin 5
IDBP-480451
importin 5
IDBP-473995
importin 5
IDBP-485424
importin 5
IDBP-474877
importin 5
IDBP-476077
importin 5
IDBP-479225
importin 5
IDBP-481655
importin 5
IDBP-484744
importin 5
IDBP-484619
importin 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:97953658-98024297
Strand Forward strand
Band q32.2
Transcripts
ENST00000357602 ENSP00000350219
ENST00000261574 ENSP00000261574
ENST00000403772 ENSP00000385938
ENST00000421861 ENSP00000408885
ENST00000482642
ENST00000460070 ENSP00000420284
ENST00000481455 ENSP00000419766
ENST00000463157 ENSP00000420149
ENST00000493281 ENSP00000419166
ENST00000471898 ENSP00000419797
ENST00000490369 ENSP00000419398
ENST00000489058 ENSP00000417993
ENST00000481689 ENSP00000420043
ENST00000480611 ENSP00000419860
ENST00000485433 ENSP00000417721
ENST00000496368 ENSP00000417162
ENST00000475420 ENSP00000420079
ENST00000480641 ENSP00000419003
ENST00000490680 ENSP00000418393
ENST00000497270 ENSP00000417647
ENST00000469360 ENSP00000419764
ENST00000473582 ENSP00000420491
ENST00000470493
ENST00000491555
ENST00000479736
ENST00000493492
ENST00000468620
ENST00000493122
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 67 [view]
Protein-Protein 67 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005095 GTPase inhibitor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0008536 Ran GTPase binding
GO:0008565 protein transporter activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006607 NLS-bearing protein import into nucleus
GO:0006610 ribosomal protein import into nucleus
GO:0006886 intracellular protein transport
GO:0016032 viral process
GO:0042307 positive regulation of protein import into nucleus
GO:0043086 negative regulation of catalytic activity
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0031965 nuclear membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030662
View Gene Order
ENSBTAG00000039374
Not yet available
Pathways
NETPATH
REACTOME
REACT_9434
vRNP Assembly pathway
REACT_6167
Influenza Infection pathway
REACT_6152
Influenza Viral RNA Transcription and Replication pathway
REACT_6145
Influenza Life Cycle pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.613802 Hs.643743 Hs.712598 Hs.715536
RefSeq NM_002271 XM_005254049 XM_005254052 XM_005254053
HUGO
OMIM
CCDS CCDS31999
HPRD 03597
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca