Version 5.4
Mus musculus Gene: Atp2b1
Summary
InnateDB Gene IDBG-187658.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atp2b1
Gene Name ATPase, Ca++ transporting, plasma membrane 1
Synonyms 2810442I22Rik; E130111D10Rik; Pmca1
Species Mus musculus
Ensembl Gene ENSMUSG00000019943
Encoded Proteins
IDBP-187660
ATPase, Ca++ transporting, plasma membrane 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070961:
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:98915152-99026143
Strand Forward strand
Band C3
Transcripts
ENSMUST00000020107 ENSMUSP00000020107
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005388 calcium-transporting ATPase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019829 cation-transporting ATPase activity
GO:0046872 metal ion binding
Biological Process
GO:0006812 cation transport
GO:0006816 calcium ion transport
GO:0008152 metabolic process
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000070961
View Gene Order
ENSBTAG00000009552
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04020
Calcium signaling pathway pathway
mmu04970
Salivary secretion pathway
mmu04972
Pancreatic secretion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23765
Reduction of cytosolic Ca++ levels pathway
REACT_23876
Platelet homeostasis pathway
REACT_25149
Ion transport by P-type ATPases pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_23905
Platelet calcium homeostasis pathway
REACT_25300
Ion channel transport pathway
REACT_604
Hemostasis pathway
KEGG
hsa04020
Calcium signaling pathway pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt
TrEMBL G5E829 Q3TC38 Q3TDJ2 Q3TSK3 Q6PG79 Q8K314
UniProt Splice Variant
Entrez Gene 67972
UniGene Mm.166944 Mm.409498 Mm.472543
RefSeq NM_026482
OMIM
CCDS CCDS24145
HPRD
IMGT
MGI ID MGI:104653
MGI Symbol Atp2b1
EMBL AC153906 AC160410 AK161995 AK170163 AK170926 BC029045 BC049262 BC057180 CH466539
GenPept AAH29045 AAH49262 AAH57180 BAE36672 BAE41609 BAE42119 EDL21639
RNA Seq Atlas 67972

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca