Version 5.4
Homo sapiens Gene: ATP2B1
Summary
InnateDB Gene IDBG-50612.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP2B1
Gene Name ATPase, Ca++ transporting, plasma membrane 1
Synonyms PMCA1; PMCA1kb
Species Homo sapiens
Ensembl Gene ENSG00000070961
Encoded Proteins
IDBP-50614
ATPase, Ca++ transporting, plasma membrane 1
IDBP-50616
ATPase, Ca++ transporting, plasma membrane 1
IDBP-244150
ATPase, Ca++ transporting, plasma membrane 1
IDBP-381016
ATPase, Ca++ transporting, plasma membrane 1
IDBP-585428
ATPase, Ca++ transporting, plasma membrane 1
IDBP-586916
ATPase, Ca++ transporting, plasma membrane 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:89588049-89709300
Strand Reverse strand
Band q21.33
Transcripts
ENST00000359142 ENSP00000352054
ENST00000261173 ENSP00000261173
ENST00000393164 ENSP00000376869
ENST00000428670 ENSP00000392043
ENST00000550716 ENSP00000447096
ENST00000552275
ENST00000551009
ENST00000549727
ENST00000549585
ENST00000551310 ENSP00000447041
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005388 calcium-transporting ATPase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019829 cation-transporting ATPase activity
GO:0046872 metal ion binding
Biological Process
GO:0006810 transport
GO:0006812 cation transport
GO:0007596 blood coagulation
GO:0008152 metabolic process
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019943
View Gene Order
ENSBTAG00000009552
Not yet available
Pathways
NETPATH
REACTOME
REACT_23765
Reduction of cytosolic Ca++ levels pathway
REACT_23876
Platelet homeostasis pathway
REACT_25149
Ion transport by P-type ATPases pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_23905
Platelet calcium homeostasis pathway
REACT_25300
Ion channel transport pathway
REACT_604
Hemostasis pathway
KEGG
hsa04020
Calcium signaling pathway pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.506276 Hs.607220 Hs.610752 Hs.705540
RefSeq NM_001001323 NM_001682
HUGO
OMIM
CCDS CCDS41817 CCDS9035
HPRD 00158
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca