Version 5.4
Mus musculus Gene: Atp6v0d1
Summary
InnateDB Gene IDBG-187917.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atp6v0d1
Gene Name ATPase, H+ transporting, lysosomal V0 subunit D1
Synonyms Ac39; AI267038; Atp6d; P39; VATX; Vma6
Species Mus musculus
Ensembl Gene ENSMUSG00000013160
Encoded Proteins
IDBP-187919
ATPase, H+ transporting, lysosomal V0 subunit D1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159720:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [provided by RefSeq, Jul 2008]
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c\', c\'\', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:105524465-105566047
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000013304 ENSMUSP00000013304
ENSMUST00000144486
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0015078 hydrogen ion transmembrane transporter activity
GO:0032403 protein complex binding
Biological Process
GO:0007420 brain development
GO:0015991 ATP hydrolysis coupled proton transport
GO:0042384 cilium assembly
Cellular Component
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005813 centrosome
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0033179 proton-transporting V-type ATPase, V0 domain
GO:0043005 neuron projection
GO:0043234 protein complex
GO:0043679 axon terminus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000159720
View Gene Order
ENSBTAG00000014553
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_240250
Signaling by Insulin receptor pathway
REACT_239697
Unfolded Protein Response (UPR) pathway
REACT_198515
Transferrin endocytosis and recycling pathway
REACT_198345
Phagosomal maturation (early endosomal stage) pathway
REACT_198347
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
REACT_247926
Metabolism of proteins pathway
REACT_205755
Iron uptake and transport pathway
REACT_231085
IRE1alpha activates chaperones pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_106572
XBP1(S) activates chaperone genes pathway
REACT_233181
Insulin receptor recycling pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu00190
Oxidative phosphorylation pathway
mmu04142
Lysosome pathway
mmu04145
Phagosome pathway
mmu04966
Collecting duct acid secretion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25283
Transferrin endocytosis and recycling pathway
REACT_25060
Iron uptake and transport pathway
REACT_1109
Insulin receptor recycling pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_121256
Phagosomal maturation (early endosomal stage) pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_111102
Signal Transduction pathway
REACT_17015
Metabolism of proteins pathway
REACT_121237
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
REACT_116125
Disease pathway
REACT_224763
Transferrin endocytosis and recycling pathway
REACT_220738
Phagosomal maturation (early endosomal stage) pathway
REACT_204342
Iron uptake and transport pathway
REACT_223103
Transmembrane transport of small molecules pathway
REACT_202485
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
REACT_214353
Signal Transduction pathway
REACT_219546
Signaling by Insulin receptor pathway
REACT_218371
IRE1alpha activates chaperones pathway
REACT_213782
Metabolism of proteins pathway
REACT_211201
XBP1(S) activates chaperone genes pathway
REACT_226614
Unfolded Protein Response (UPR) pathway
REACT_226147
Insulin receptor recycling pathway
REACT_207087
Disease pathway
KEGG
hsa05110
Vibrio cholerae infection pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa00190
Oxidative phosphorylation pathway
hsa04142
Lysosome pathway
hsa04966
Collecting duct acid secretion pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.17708 Mm.462635
RefSeq NM_013477
OMIM
CCDS CCDS22604
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca