InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp6v0d1

Summary

InnateDB Protein

IDBP-187919.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6v0d1

Protein Name

ATPase, H+ transporting, lysosomal V0 subunit D1

Synonyms

Ac39; AI267038; Atp6d; P39; VATX; Vma6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000013304

InnateDB Gene

IDBG-187917 (Atp6v0d1)

Protein Structure

UniProt Annotation

Function

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Localizes to centrosome and the base of the cilium. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:12527205, ECO:0000269PubMed:12963731}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0032403	protein complex binding

Biological Process

GO:0007420	brain development
GO:0015991	ATP hydrolysis coupled proton transport
GO:0042384	cilium assembly

Cellular Component

GO:0005765	lysosomal membrane
GO:0005769	early endosome
GO:0005813	centrosome
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0033179	proton-transporting V-type ATPase, V0 domain
GO:0043005	neuron projection
GO:0043234	protein complex
GO:0043679	axon terminus
GO:0070062	extracellular vesicular exosome