Version 5.4
Mus musculus Gene: Eif2c3
Summary
InnateDB Gene IDBG-188535.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif2c3
Gene Name eukaryotic translation initiation factor 2C, 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000028842
Encoded Proteins
IDBP-188541
eukaryotic translation initiation factor 2C, 3
IDBP-540202
eukaryotic translation initiation factor 2C, 3
IDBP-534094
eukaryotic translation initiation factor 2C, 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126070:
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:126331704-126429556
Strand Reverse strand
Band D2.2
Transcripts
ENSMUST00000069097 ENSMUSP00000066633
ENSMUST00000132123 ENSMUSP00000116204
ENSMUST00000127831 ENSMUSP00000118577
ENSMUST00000151179
ENSMUST00000155645
ENSMUST00000123233
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0035198 miRNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006402 mRNA catabolic process
GO:0035278 negative regulation of translation involved in gene silencing by miRNA
GO:0072091 regulation of stem cell proliferation
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0016020 membrane
GO:0016442 RISC complex
GO:0035068 micro-ribonucleoprotein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000126070
View Gene Order
ENSBTAG00000018324
Not yet available
Pathways
NETPATH
REACTOME
REACT_198208
Post-transcriptional silencing by small RNAs pathway
REACT_221178
MicroRNA (miRNA) biogenesis pathway
REACT_233572
Gene Expression pathway
REACT_206535
Regulatory RNA pathways pathway
REACT_201975
Small interfering RNA (siRNA) biogenesis pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_118568
Pre-NOTCH Transcription and Translation pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_12417
MicroRNA (miRNA) biogenesis pathway
REACT_118699
Post-transcriptional silencing by small RNAs pathway
REACT_118560
Small interfering RNA (siRNA) biogenesis pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_120956
Cellular responses to stress pathway
REACT_169325
Oncogene Induced Senescence pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_172761
Ca2+ pathway pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_299
Signaling by NOTCH pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_12472
Regulatory RNA pathways pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A3KFX6
UniProt Splice Variant
Entrez Gene 214150
UniGene Mm.397701 Mm.418298 Mm.440915 Mm.482388 Mm.483093
RefSeq NM_153402 XM_006502918 XM_006502919 XM_006502920 XM_006502921
OMIM
CCDS CCDS18652
HPRD
IMGT
MGI ID MGI:2446634
MGI Symbol Ago3
EMBL AL606976
GenPept
RNA Seq Atlas 214150

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca