InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EIF2C3

Summary

InnateDB Gene

IDBG-96250.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF2C3

Gene Name

eukaryotic translation initiation factor 2C, 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000126070

Encoded Proteins

IDBP-96252

eukaryotic translation initiation factor 2C, 3

IDBP-96254

eukaryotic translation initiation factor 2C, 3

IDBP-96258

eukaryotic translation initiation factor 2C, 3

IDBP-234465

eukaryotic translation initiation factor 2C, 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:35930718-36072500

Strand

Forward strand

Band

p34.3

Transcripts

ENST00000324350	ENSP00000317425
ENST00000373191	ENSP00000362287
ENST00000246314	ENSP00000246314
ENST00000397828	ENSP00000380928
ENST00000491443
ENST00000466576
ENST00000479395
ENST00000471099

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.

Experimentally validated
Total	66 [view]
Protein-Protein	65 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0005515	protein binding
GO:0035198	miRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006402	mRNA catabolic process
GO:0006413	translational initiation
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010467	gene expression
GO:0035278	negative regulation of translation involved in gene silencing by miRNA
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0072091	regulation of stem cell proliferation