Homo sapiens Gene: EIF2C3 | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-96250.6 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | EIF2C3 | ||||||||||||||||||||||||
Gene Name | eukaryotic translation initiation factor 2C, 3 | ||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||
Ensembl Gene | ENSG00000126070 | ||||||||||||||||||||||||
Encoded Proteins |
eukaryotic translation initiation factor 2C, 3
eukaryotic translation initiation factor 2C, 3
eukaryotic translation initiation factor 2C, 3
eukaryotic translation initiation factor 2C, 3
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Protein Structure | |||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
Summary |
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 1:35930718-36072500 | ||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||
Band | p34.3 | ||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||
REACTOME |
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
PI3K/AKT activation pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Pre-NOTCH Transcription and Translation pathway
PI-3K cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
MicroRNA (miRNA) biogenesis pathway
Post-transcriptional silencing by small RNAs pathway
Small interfering RNA (siRNA) biogenesis pathway
Signaling by FGFR in disease pathway
Cellular responses to stress pathway
Oncogene Induced Senescence pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Ca2+ pathway pathway
Pre-NOTCH Expression and Processing pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Adaptive Immune System pathway
Immune System pathway
Cellular Senescence pathway
NGF signalling via TRKA from the plasma membrane pathway
Signaling by NOTCH pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by the B Cell Receptor (BCR) pathway
Oxidative Stress Induced Senescence pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Gene Expression pathway
Disease pathway
Regulatory RNA pathways pathway
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KEGG | |||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
UniGene | Hs.613686 Hs.657659 Hs.657676 | ||||||||||||||||||||||||
RefSeq | NM_024852 NM_177422 XM_005270575 XM_005270576 XM_006710404 | ||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | CCDS399 CCDS400 | ||||||||||||||||||||||||
HPRD | 09558 | ||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||