Mus musculus Gene: Eif2c1
Summary
InnateDB Gene IDBG-188602.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif2c1
Gene Name eukaryotic translation initiation factor 2C, 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000041530
Encoded Proteins
eukaryotic translation initiation factor 2C, 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092847:
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and argonaute 4. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:126435012-126468583
Strand Reverse strand
Band D2.2
Transcripts
ENSMUST00000097888 ENSMUSP00000095498
ENSMUST00000127800 ENSMUSP00000135662
ENSMUST00000156533
ENSMUST00000149425
ENSMUST00000176315 ENSMUSP00000134871
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0035278 negative regulation of translation involved in gene silencing by miRNA
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005737 cytoplasm
GO:0005844 polysome
GO:0030529 ribonucleoprotein complex
GO:0035068 micro-ribonucleoprotein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Post-transcriptional silencing by small RNAs pathway
MicroRNA (miRNA) biogenesis pathway
Transcriptional regulation by small RNAs pathway
Gene Expression pathway
Regulatory RNA pathways pathway
Small interfering RNA (siRNA) biogenesis pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
PI3K/AKT activation pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Pre-NOTCH Transcription and Translation pathway
PI-3K cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
MicroRNA (miRNA) biogenesis pathway
Post-transcriptional silencing by small RNAs pathway
Small interfering RNA (siRNA) biogenesis pathway
Signaling by FGFR in disease pathway
Cellular responses to stress pathway
Oncogene Induced Senescence pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Ca2+ pathway pathway
Pre-NOTCH Expression and Processing pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Innate Immune System pathway
Transcriptional regulation by small RNAs pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Adaptive Immune System pathway
Immune System pathway
Cellular Senescence pathway
NGF signalling via TRKA from the plasma membrane pathway
Signaling by NOTCH pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by the B Cell Receptor (BCR) pathway
Oxidative Stress Induced Senescence pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Gene Expression pathway
Disease pathway
Regulatory RNA pathways pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.30800 Mm.408591 Mm.471222
RefSeq NM_153403 XM_006503067
OMIM
CCDS CCDS18653
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas