InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eif2c1

Summary

InnateDB Protein

IDBP-188604.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif2c1

Protein Name

eukaryotic translation initiation factor 2C, 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095498

InnateDB Gene

IDBG-188602 (Eif2c1)

Protein Structure

UniProt Annotation

Function

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. May also be required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). {ECO:0000269PubMed:19174539}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000956	nuclear-transcribed mRNA catabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0035278	negative regulation of translation involved in gene silencing by miRNA

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005737	cytoplasm
GO:0005844	polysome
GO:0030529	ribonucleoprotein complex
GO:0035068	micro-ribonucleoprotein complex

Protein Structure and Domains

PDB ID

MGI:2446630

InterPro

IPR003100 Argonaute/Dicer protein, PAZ domain
IPR003165 Stem cell self-renewal protein Piwi
IPR012337 Ribonuclease H-like domain
IPR014811 Domain of unknown function DUF1785

PFAM

PF02170
PF02171
PF08699

PRINTS

PIRSF

SMART

SM00949
SM00950

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CJG1