Version 5.4
Mus musculus Gene: Pik3r5
Summary
InnateDB Gene IDBG-188688.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pik3r5
Gene Name phosphoinositide-3-kinase, regulatory subunit 5, p101
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000020901
Encoded Proteins
IDBP-188690
phosphoinositide-3-kinase, regulatory subunit 5, p101
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141506:
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:68432121-68497849
Strand Forward strand
Band B3
Transcripts
ENSMUST00000021283 ENSMUSP00000021283
ENSMUST00000154220
ENSMUST00000141716
ENSMUST00000126876
ENSMUST00000155887
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0043406 positive regulation of MAP kinase activity
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0051897 positive regulation of protein kinase B signaling
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0005944 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000141506
View Gene Order
ENSBTAG00000005978
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_198973
Synthesis of PIPs at the plasma membrane pathway
REACT_224553
Hemostasis pathway
REACT_254215
Signaling by GPCR pathway
REACT_199016
PI Metabolism pathway
REACT_188937
Metabolism pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_220092
GPVI-mediated activation cascade pathway
REACT_188643
Phospholipid metabolism pathway
REACT_207835
G-protein beta:gamma signalling pathway
REACT_188257
Signal Transduction pathway
REACT_223974
G beta:gamma signalling through PI3Kgamma pathway
KEGG
mmu05213
Endometrial cancer pathway
mmu05211
Renal cell carcinoma pathway
mmu04012
ErbB signaling pathway pathway
mmu04930
Type II diabetes mellitus pathway
mmu04370
VEGF signaling pathway pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04910
Insulin signaling pathway pathway
mmu05221
Acute myeloid leukemia pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04620
Toll-like receptor signaling pathway pathway
mmu05210
Colorectal cancer pathway
mmu04664
Fc epsilon RI signaling pathway pathway
mmu05218
Melanoma pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu04070
Phosphatidylinositol signaling system pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu05214
Glioma pathway
mmu04150
mTOR signaling pathway pathway
mmu05222
Small cell lung cancer pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu04210
Apoptosis pathway
mmu05215
Prostate cancer pathway
mmu05220
Chronic myeloid leukemia pathway
mmu05223
Non-small cell lung cancer pathway
mmu04510
Focal adhesion pathway
mmu04662
B cell receptor signaling pathway pathway
mmu05212
Pancreatic cancer pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04062
Chemokine signaling pathway pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu05200
Pathways in cancer pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
mmu04960
Aldosterone-regulated sodium reabsorption pathway
mmu05146
Amoebiasis pathway
mmu04380
Osteoclast differentiation pathway
mmu04973
Carbohydrate digestion and absorption pathway
mmu05145
Toxoplasmosis pathway
mmu05160
Hepatitis C pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1695
GPVI-mediated activation cascade pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04150
mTOR signaling pathway pathway
hsa05221
Acute myeloid leukemia pathway
hsa04370
VEGF signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa05210
Colorectal cancer pathway
hsa05223
Non-small cell lung cancer pathway
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa04210
Apoptosis pathway
hsa05218
Melanoma pathway
hsa05213
Endometrial cancer pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa05214
Glioma pathway
hsa05222
Small cell lung cancer pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04910
Insulin signaling pathway pathway
hsa04662
B cell receptor signaling pathway pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05212
Pancreatic cancer pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04960
Aldosterone-regulated sodium reabsorption pathway
hsa05146
Amoebiasis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04380
Osteoclast differentiation pathway
hsa05145
Toxoplasmosis pathway
hsa04973
Carbohydrate digestion and absorption pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.244960
RefSeq NM_177320 XM_006533548
OMIM
CCDS CCDS24865
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca