InnateDB Protein
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IDBP-188690.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pik3r5
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Protein Name
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phosphoinositide-3-kinase, regulatory subunit 5, p101
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000021283
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InnateDB Gene
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IDBG-188688 (Pik3r5)
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Protein Structure
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Function |
Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
Accession |
GO Term |
GO:0031683
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G-protein beta/gamma-subunit complex binding
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GO:0046935
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1-phosphatidylinositol-3-kinase regulator activity
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Biological Process |
GO:0007186
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G-protein coupled receptor signaling pathway
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GO:0014065
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phosphatidylinositol 3-kinase signaling
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GO:0043406
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positive regulation of MAP kinase activity
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GO:0043551
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regulation of phosphatidylinositol 3-kinase activity
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GO:0051897
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positive regulation of protein kinase B signaling
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Cellular Component |
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PDB ID |
MGI:2443588
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InterPro |
IPR019522
Phosphoinositide 3-kinase regulatory subunit 5/6
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PFAM |
PF10486
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5SW28
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PhosphoSite |
PhosphoSite-Q5SW28
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TrEMBL |
A1A4T4
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UniProt Splice Variant |
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Entrez Gene |
320207
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UniGene |
Mm.244960
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RefSeq |
NP_796294
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MGI ID |
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MGI Symbol |
Pik3r5
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OMIM |
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CCDS |
CCDS24865
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HPRD |
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IMGT |
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EMBL |
AK089483
AK149847
AK161050
AL606831
AY156924
BC128076
BC128077
CH466601
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GenPept |
AAI28077
AAI28078
AAN84787
BAC40901
BAE29119
BAE36171
CAI25692
EDL10448
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