Version 5.4
| Homo sapiens Gene: KLRC4 | |||
|---|---|---|---|
| Summary | |||
| InnateDB Gene | IDBG-18873.6 | ||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||
| Gene Symbol | KLRC4 | ||
| Gene Name | killer cell lectin-like receptor subfamily C, member 4 | ||
| Synonyms | NKG2-F; NKG2F | ||
| Species | Homo sapiens | ||
| Ensembl Gene | ENSG00000183542 | ||
| Encoded Proteins |
killer cell lectin-like receptor subfamily C, member 4
|
||
| Protein Structure |
|
||
| Useful resources | Stemformatics EHFPI ImmGen | ||
| Entrez Gene | |||
| Summary |
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member. [provided by RefSeq, Dec 2010] |
||
| Gene Information | |||
| Type | Protein coding | ||
| Genomic Location | Chromosome 12:10407382-10409757 | ||
| Strand | Reverse strand | ||
| Band | p13.2 | ||
| Transcripts |
|
||
| Interactions | |||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
||
| Gene Ontology | |||
Molecular Function |
|
||
| Biological Process |
|
||
| Cellular Component |
|
||
| Orthologs | |||
| No orthologs found for this gene | |||
| Pathways | |||
| NETPATH | |||
| REACTOME | |||
| KEGG |
Antigen processing and presentation pathway
|
||
| INOH | |||
| PID NCI | |||
| Cross-References | |||
| SwissProt | O43908 | ||
| TrEMBL | H3BRK7 H3BU71 | ||
| UniProt Splice Variant | |||
| Entrez Gene | 8302 | ||
| UniGene | |||
| RefSeq | NM_013431 | ||
| HUGO | HGNC:6377 | ||
| OMIM | 602893 | ||
| CCDS | CCDS8624 | ||
| HPRD | |||
| IMGT | |||
| EMBL | AC022075 AF027164 AF350018 AF350019 AJ001683 AJ001686 BC017784 U96845 U96846 | ||
| GenPept | AAC17491 AAC51909 AAC51910 AAH17784 AAK83805 AAK83806 CAA04921 CAA04924 | ||
| RNA Seq Atlas | 8302 | ||