Version 5.4
Homo sapiens Gene: TIMP4
Summary
InnateDB Gene IDBG-18927.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIMP4
Gene Name TIMP metallopeptidase inhibitor 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000157150
Encoded Proteins
IDBP-18929
TIMP metallopeptidase inhibitor 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:12153051-12159351
Strand Reverse strand
Band p25.2
Transcripts
ENST00000287814 ENSP00000287814
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008191 metalloendopeptidase inhibitor activity
GO:0046872 metal ion binding
Biological Process
GO:0007417 central nervous system development
GO:0008150 biological_process
GO:0009725 response to hormone
GO:0010951 negative regulation of endopeptidase activity
GO:0032496 response to lipopolysaccharide
GO:0034097 response to cytokine
GO:0042493 response to drug
GO:0042698 ovulation cycle
GO:0043434 response to peptide hormone
Cellular Component
GO:0005615 extracellular space
GO:0030017 sarcomere
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030317
View Gene Order
ENSBTAG00000020263
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591665 Hs.680672
RefSeq NM_003256
HUGO
OMIM
CCDS CCDS2608
HPRD 03557
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca