InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TIMP4

Summary

InnateDB Protein

IDBP-18929.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIMP4

Protein Name

TIMP metallopeptidase inhibitor 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000287814

InnateDB Gene

IDBG-18927 (TIMP4)

Protein Structure

UniProt Annotation

Function

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP- 9.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Abundant in heart and present at low levels in many other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008191	metalloendopeptidase inhibitor activity
GO:0046872	metal ion binding

Biological Process

GO:0007417	central nervous system development
GO:0008150	biological_process
GO:0009725	response to hormone
GO:0010951	negative regulation of endopeptidase activity
GO:0032496	response to lipopolysaccharide
GO:0034097	response to cytokine
GO:0042493	response to drug
GO:0042698	ovulation cycle
GO:0043434	response to peptide hormone

Cellular Component

GO:0005615	extracellular space
GO:0030017	sarcomere

Protein Structure and Domains

PDB ID

InterPro

IPR001134 Netrin domain
IPR001820 Proteinase inhibitor I35, tissue inhibitor of metalloproteinase
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold

PFAM

PF00965

PRINTS

PIRSF

SMART

SM00206

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99727