Version 5.4
Mus musculus Gene: Hoxc8
Summary
InnateDB Gene IDBG-189364.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hoxc8
Gene Name homeobox C8
Synonyms D130011F21Rik; Hox-3.1
Species Mus musculus
Ensembl Gene ENSMUSG00000001657
Encoded Proteins
IDBP-189366
homeobox C8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000037965:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:102990607-102994111
Strand Forward strand
Band F3
Transcripts
ENSMUST00000001703 ENSMUSP00000001703
ENSMUST00000189484
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0009952 anterior/posterior pattern specification
GO:0030182 neuron differentiation
GO:0048705 skeletal system morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000037965
View Gene Order
ENSBTAG00000012149
Not yet available
Cross-References
SwissProt P09025
TrEMBL Q8BNV9 Q8BNX6 Q8BQA3
UniProt Splice Variant
Entrez Gene 15426
UniGene Mm.6167
RefSeq NM_010466
OMIM
CCDS CCDS27894
HPRD
IMGT
MGI ID MGI:96198
MGI Symbol Hoxc8
EMBL AK051173 AK079948 AK080107 M35603 X03659 X07439 X07646
GenPept AAA37857 BAC34544 BAC37790 BAC37827 CAA27294 CAA30319 CAA30486
RNA Seq Atlas 15426

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca