InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Herc2

Summary

InnateDB Gene

IDBG-189382.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Herc2

Gene Name

hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2

Synonyms

D15F32S1h; D7H15F32S1; D7H15F37S1; jdf2; mKIAA0393; rjs

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030451

Encoded Proteins

IDBP-189384

hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2

IDBP-625785

hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128731:
This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:56050155-56231794

Strand

Forward strand

Band

Transcripts

ENSMUST00000076226	ENSMUSP00000075579
ENSMUST00000164095	ENSMUSP00000131573

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0020037	heme binding
GO:0031625	ubiquitin protein ligase binding
GO:0032183	SUMO binding
GO:0046872	metal ion binding

Biological Process

GO:0006281	DNA repair
GO:0006974	cellular response to DNA damage stimulus
GO:0007283	spermatogenesis
GO:0016567	protein ubiquitination
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005743	mitochondrial inner membrane
GO:0005814	centriole
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000128731

View Gene Order

ENSBTAG00000013916

Not yet available

Pathways

NETPATH

REACTOME

REACT_236645

Class I MHC mediated antigen processing & presentation pathway

REACT_230745

Immune System pathway

REACT_199115

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_229531

Adaptive Immune System pathway

KEGG

mmu04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Cross-References

SwissProt

Q4U2R1

TrEMBL

UniProt Splice Variant

Entrez Gene

15204

UniGene

Mm.20929 Mm.403529

RefSeq

XM_006540638 NM_010418 XM_006540637

OMIM

CCDS

CCDS21318

HPRD

IMGT

MGI ID

MGI:103234

MGI Symbol

Herc2

EMBL

AC102121 AC102150 AF061529 AF071173 AK141515 AK148361 AK161826 AK162270 AK162708 AK220338 BC044667 BC054829

GenPept

AAC31431 AAD08658 AAH44667 AAH54829 BAD90404 BAE24711 BAE28504 BAE36593 BAE36828 BAE37031

RNA Seq Atlas

15204