InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HERC2

Summary

InnateDB Gene

IDBG-4485.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HERC2

Gene Name

HECT and RLD domain containing E3 ubiquitin protein ligase 2

Synonyms

D15F37S1; jdf2; MRT38; p528; SHEP1

Species

Homo sapiens

Ensembl Gene

ENSG00000128731

Encoded Proteins

IDBP-4487

hect domain and RLD 2

IDBP-747488

IDBP-746755

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:28111040-28322152

Strand

Reverse strand

Band

q13.1

Transcripts

ENST00000261609	ENSP00000261609
ENST00000564383
ENST00000566635
ENST00000563945
ENST00000569772	ENSP00000457745
ENST00000569335
ENST00000567869
ENST00000563670
ENST00000564519
ENST00000564734	ENSP00000456237
ENST00000562136
ENST00000568206

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	58 [view]
Protein-Protein	57 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0020037	heme binding
GO:0031625	ubiquitin protein ligase binding
GO:0032183	SUMO binding
GO:0046872	metal ion binding

Biological Process

GO:0006281	DNA repair
GO:0006886	intracellular protein transport
GO:0006974	cellular response to DNA damage stimulus
GO:0007283	spermatogenesis
GO:0016567	protein ubiquitination
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005743	mitochondrial inner membrane
GO:0005814	centriole
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030451

View Gene Order

ENSBTAG00000013916

Not yet available

Pathways

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.434890 Hs.655872 Hs.722313 Hs.722755 Hs.741019

RefSeq

NM_004667 XM_005268276 XM_005268277 XM_006720726 XM_006720727

HUGO

OMIM

CCDS

CCDS10021

HPRD

06905

IMGT

EMBL

GenPept

RNA Seq Atlas