Version 5.4
Homo sapiens Gene: FEM1B
Summary
InnateDB Gene IDBG-18948.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FEM1B
Gene Name fem-1 homolog b (C. elegans)
Synonyms F1A-ALPHA; F1AA; FEM1-beta
Species Homo sapiens
Ensembl Gene ENSG00000169018
Encoded Proteins
IDBP-18950
fem-1 homolog b (C. elegans)
IDBP-747888
IDBP-744858
IDBP-745066
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:68277803-68295865
Strand Forward strand
Band q23
Transcripts
ENST00000306917 ENSP00000307298
ENST00000566008 ENSP00000456968
ENST00000570067 ENSP00000457002
ENST00000566739 ENSP00000457342
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 32 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005123 death receptor binding
GO:0005515 protein binding
Biological Process
GO:0002070 epithelial cell maturation
GO:0006915 apoptotic process
GO:0016567 protein ubiquitination
GO:0051438 regulation of ubiquitin-protein ligase activity
GO:0060442 branching involved in prostate gland morphogenesis
GO:0060743 epithelial cell maturation involved in prostate gland development
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000001 regulation of DNA damage checkpoint
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032244
View Gene Order
ENSBTAG00000008378
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592737 Hs.606572 Hs.713022
RefSeq NM_015322
HUGO
OMIM
CCDS CCDS10228
HPRD 16889
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca