Version 5.4
Bos taurus Gene: FEM1B
Summary
InnateDB Gene IDBG-645493.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FEM1B
Gene Name protein fem-1 homolog B
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008378
Encoded Proteins
IDBP-698194
fem-1 homolog b (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169018:
This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:15080222-15092340
Strand Forward strand
Band
Transcripts
ENSBTAT00000011028 ENSBTAP00000011028
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005123 death receptor binding
GO:0005515 protein binding
Biological Process
GO:0002070 epithelial cell maturation
GO:0051438 regulation of ubiquitin-protein ligase activity
GO:0060442 branching involved in prostate gland morphogenesis
GO:0060743 epithelial cell maturation involved in prostate gland development
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000001 regulation of DNA damage checkpoint
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000169018
View Gene Order
ENSMUSG00000032244
View Gene Order
Cross-References
SwissProt
TrEMBL F1N162
UniProt Splice Variant
Entrez Gene 540252
UniGene Bt.45478
RefSeq NM_001192383
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02027926
GenPept
RNA Seq Atlas 540252

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca