InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: S1pr1

Summary

InnateDB Gene

IDBG-189693.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S1pr1

Gene Name

sphingosine-1-phosphate receptor 1

Synonyms

AI849002; Edg1; Lpb1; S1p; S1p1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000045092

Encoded Proteins

IDBP-189695

sphingosine-1-phosphate receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25024218

T-cell-intrinsic Mir155 is required for type-2 immunity, in part through regulation of S1pr1, whereas T-cell-intrinsic Mir146 is required to prevent overt Th1/Th17 skewing.

Entrez Gene

Summary

This gene encodes a G-protein-coupled receptor bound by the lysophospholipid, sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. This receptor is highly expressed in T and B lymphocytes, and it plays a role in T cell and B cell export from peripheral lymphoid organs. This protein is bound and downregulated by FTY720, an exogenous immunosuppressant drug studied in mouse disease models for multiple sclerosis in humans. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:115710433-115715055

Strand

Reverse strand

Band

Transcripts

ENSMUST00000055676

ENSMUSP00000050897

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0004930	G-protein coupled receptor activity
GO:0038036	sphingosine-1-phosphate receptor activity
GO:0046625	sphingolipid binding

Biological Process

GO:0001525	angiogenesis
GO:0001955	blood vessel maturation
GO:0003245	cardiac muscle tissue growth involved in heart morphogenesis
GO:0003376	sphingosine-1-phosphate signaling pathway
GO:0006935	chemotaxis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007420	brain development
GO:0008284	positive regulation of cell proliferation
GO:0016477	cell migration
GO:0019226	transmission of nerve impulse
GO:0030032	lamellipodium assembly
GO:0030155	regulation of cell adhesion
GO:0030182	neuron differentiation
GO:0030335	positive regulation of cell migration
GO:0030500	regulation of bone mineralization
GO:0031532	actin cytoskeleton reorganization
GO:0032320	positive regulation of Ras GTPase activity
GO:0045087	innate immune response (InnateDB)
GO:0045124	regulation of bone resorption
GO:0045446	endothelial cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050927	positive regulation of positive chemotaxis
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051497	negative regulation of stress fiber assembly
GO:0061384	heart trabecula morphogenesis
GO:0072678	T cell migration

Cellular Component

GO:0005768	endosome
GO:0005901	caveola
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0031226	intrinsic component of plasma membrane