InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: S1PR1

Summary

InnateDB Gene

IDBG-636083.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S1PR1

Gene Name

Sphingosine 1-phosphate receptor 1

Synonyms

EDG1; S1P1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005990

Encoded Proteins

IDBP-687975

Sphingosine 1-phosphate receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25024218

[Mus musculus] T-cell-intrinsic Mir155 is required for type-2 immunity, in part through regulation of S1pr1, whereas T-cell-intrinsic Mir146 is required to prevent overt Th1/Th17 skewing.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170989:
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:42184097-42188752

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000007861

ENSBTAP00000007861

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0038036	sphingosine-1-phosphate receptor activity

Biological Process

GO:0001525	angiogenesis
GO:0001955	blood vessel maturation
GO:0003245	cardiac muscle tissue growth involved in heart morphogenesis
GO:0003376	sphingosine-1-phosphate signaling pathway
GO:0006935	chemotaxis
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007420	brain development
GO:0008284	positive regulation of cell proliferation
GO:0016477	cell migration
GO:0030032	lamellipodium assembly
GO:0030155	regulation of cell adhesion
GO:0030500	regulation of bone mineralization
GO:0031532	actin cytoskeleton reorganization
GO:0045124	regulation of bone resorption
GO:0061384	heart trabecula morphogenesis
GO:0072678	T cell migration

Cellular Component

GO:0005768	endosome
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031226	intrinsic component of plasma membrane
GO:0045121	membrane raft