InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cd27

Summary

InnateDB Gene

IDBG-189750.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd27

Gene Name

CD27 antigen

Synonyms

S152; Tnfrsf7; Tp55

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030336

Encoded Proteins

IDBP-189752

CD27 antigen

IDBP-256344

CD27 antigen

IDBP-256346

CD27 antigen

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 9582383

[Homo sapiens] CD27 is a member of the tumour necrosis factor receptor superfamily that activates NF-kappaB and MAPK9 (stress-activated protein kinase/c-Jun N-terminal kinase) via TRAF2, TRAF5 and MAP3K14 (NIK).

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139193:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:125232622-125237010

Strand

Reverse strand

Band

Transcripts

ENSMUST00000032486	ENSMUSP00000032486
ENSMUST00000112282	ENSMUSP00000107901
ENSMUST00000112281	ENSMUSP00000107900
ENSMUST00000135205
ENSMUST00000151527
ENSMUST00000152650

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	2 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Biological Process

GO:0042100	B cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0045471	response to ethanol
GO:0045582	positive regulation of T cell differentiation
GO:0046330	positive regulation of JNK cascade
GO:0048305	immunoglobulin secretion
GO:0070233	negative regulation of T cell apoptotic process
GO:0097191	extrinsic apoptotic signaling pathway

Cellular Component

GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000139193

View Gene Order

ENSBTAG00000014725

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04060

Cytokine-cytokine receptor interaction pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.367714

RefSeq

NM_001033126 NM_001042564 NM_001286753

OMIM

CCDS

CCDS39638 CCDS39639 CCDS71839

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas