Version 5.4
Bos taurus Gene: CD27
Summary
InnateDB Gene IDBG-640494.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD27
Gene Name CD27 antigen precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014725
Encoded Proteins
IDBP-692765
CD27 antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 9582383
[Homo sapiens] CD27 is a member of the tumour necrosis factor receptor superfamily that activates NF-kappaB and MAPK9 (stress-activated protein kinase/c-Jun N-terminal kinase) via TRAF2, TRAF5 and MAP3K14 (NIK).
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139193:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:104302583-104308155
Strand Reverse strand
Band
Transcripts
ENSBTAT00000019595 ENSBTAP00000019595
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0046330 positive regulation of JNK cascade
GO:0070233 negative regulation of T cell apoptotic process
GO:0097191 extrinsic apoptotic signaling pathway
Cellular Component
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000139193
View Gene Order
ENSMUSG00000030336
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
mmu04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1N4E2
UniProt Splice Variant
Entrez Gene 512514
UniGene Bt.16237
RefSeq NM_001082434 XM_005207175
HUGO HGNC:11922
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02014466
GenPept
RNA Seq Atlas 512514

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca