Version 5.4
Mus musculus Gene: Per1
Summary
InnateDB Gene IDBG-189776.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Per1
Gene Name period homolog 1 (Drosophila)
Synonyms m-rigui; mPer1; Per
Species Mus musculus
Ensembl Gene ENSMUSG00000020893
Encoded Proteins
IDBP-189778
period homolog 1 (Drosophila)
IDBP-189780
period homolog 1 (Drosophila)
IDBP-189784
period homolog 1 (Drosophila)
IDBP-539647
period homolog 1 (Drosophila)
IDBP-540312
period homolog 1 (Drosophila)
IDBP-627531
period homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:69095217-69109960
Strand Forward strand
Band B3
Transcripts
ENSMUST00000021271 ENSMUSP00000021271
ENSMUST00000102605 ENSMUSP00000099665
ENSMUST00000101004 ENSMUSP00000098566
ENSMUST00000132462 ENSMUSP00000122164
ENSMUST00000142392 ENSMUSP00000121713
ENSMUST00000166748 ENSMUSP00000132635
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000989 transcription factor binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019900 kinase binding
GO:0031490 chromatin DNA binding
GO:0031625 ubiquitin protein ligase binding
GO:0070888 E-box binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002028 regulation of sodium ion transport
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0007623 circadian rhythm
GO:0009416 response to light stimulus
GO:0010608 posttranscriptional regulation of gene expression
GO:0032922 circadian regulation of gene expression
GO:0042634 regulation of hair cycle
GO:0042752 regulation of circadian rhythm
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043153 entrainment of circadian clock by photoperiod
GO:0043966 histone H3 acetylation
GO:0043967 histone H4 acetylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046329 negative regulation of JNK cascade
GO:0070932 histone H3 deacetylation
GO:0097167 circadian regulation of translation
GO:1900015 regulation of cytokine production involved in inflammatory response
GO:1900744 regulation of p38MAPK cascade
GO:2000323 negative regulation of glucocorticoid receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000179094
View Gene Order
ENSBTAG00000003889
Not yet available
Pathways
NETPATH
REACTOME
REACT_24972
Circadian Clock pathway
REACT_200794
Mus musculus biological processes pathway
REACT_241925
Circadian Clock pathway
REACT_198620
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
KEGG
mmu04710
Circadian rhythm pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_24941
Circadian Clock pathway
KEGG
hsa04710
Circadian rhythm pathway
INOH
PID NCI
circadianpathway
Circadian rhythm pathway
Cross-References
SwissProt O35973
TrEMBL B0QZN6 Q9JII8
UniProt Splice Variant
Entrez Gene 18626
UniGene Mm.7373
RefSeq NM_001159367 NM_011065 XM_006532480
OMIM
CCDS CCDS24882
HPRD
IMGT
MGI ID MGI:1098283
MGI Symbol Per1
EMBL AB002108 AB030818 AF022992 AF223952 AL645527
GenPept AAC53355 AAF87329 BAA22634 BAA94086 CAI35245
RNA Seq Atlas 18626

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca