InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mcm6

Summary

InnateDB Gene

IDBG-189829.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mcm6

Gene Name

minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)

Synonyms

ASP-l1; D1Wsu22e; Mcmd6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026355

Encoded Proteins

IDBP-189831

minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)

IDBP-789310

minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000076003:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:128331590-128359664

Strand

Reverse strand

Band

Transcripts

ENSMUST00000027601	ENSMUSP00000027601
ENSMUST00000190495	ENSMUSP00000140308
ENSMUST00000191454
ENSMUST00000188755

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	74 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0003697	single-stranded DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016851	magnesium chelatase activity
GO:0042802	identical protein binding

Biological Process

GO:0006260	DNA replication
GO:0006268	DNA unwinding involved in DNA replication
GO:0006270	DNA replication initiation
GO:0007049	cell cycle
GO:0015979	photosynthesis
GO:0015995	chlorophyll biosynthetic process