Version 5.4
Mus musculus Gene: Phc2
Summary
InnateDB Gene IDBG-190107.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Phc2
Gene Name polyhomeotic-like 2 (Drosophila)
Synonyms A3galt2; AA415044; D130050K19Rik; D4Ertd810e; Edr2; Mph2; p36
Species Mus musculus
Ensembl Gene ENSMUSG00000028796
Encoded Proteins
IDBP-190109
polyhomeotic-like 2 (Drosophila)
IDBP-269512
polyhomeotic-like 2 (Drosophila)
IDBP-269514
polyhomeotic-like 2 (Drosophila)
IDBP-400238
polyhomeotic-like 2 (Drosophila)
IDBP-536361
polyhomeotic-like 2 (Drosophila)
IDBP-538976
polyhomeotic-like 2 (Drosophila)
IDBP-533340
polyhomeotic-like 2 (Drosophila)
IDBP-537717
polyhomeotic-like 2 (Drosophila)
IDBP-538755
polyhomeotic-like 2 (Drosophila)
IDBP-533830
polyhomeotic-like 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134686:
In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
In Drosophila melanogaster, the \'Polycomb\' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein \'polyhomeotic\' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:128654702-128752881
Strand Forward strand
Band D2.2
Transcripts
ENSMUST00000030588 ENSMUSP00000030588
ENSMUST00000106080 ENSMUSP00000101690
ENSMUST00000106079 ENSMUSP00000101689
ENSMUST00000120946 ENSMUSP00000113875
ENSMUST00000136377 ENSMUSP00000116333
ENSMUST00000148723
ENSMUST00000155653
ENSMUST00000143632 ENSMUSP00000120468
ENSMUST00000138445 ENSMUSP00000117688
ENSMUST00000133439 ENSMUSP00000117163
ENSMUST00000147572 ENSMUSP00000118298
ENSMUST00000134421 ENSMUSP00000123307
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 23 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
Cellular Component
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0031519 PcG protein complex
GO:0035102 PRC1 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134686
View Gene Order
ENSBTAG00000004603
Not yet available
Pathways
NETPATH
REACTOME
REACT_188970
Oxidative Stress Induced Senescence pathway
REACT_188957
Cellular responses to stress pathway
REACT_188820
Cellular Senescence pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_169274
Cellular Senescence pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.259103 Mm.420589 Mm.487711 Mm.490300
RefSeq NM_001195083 NM_001195130 NM_018774 XM_006503237 XM_006503238 XM_006537011
OMIM
CCDS CCDS18674 CCDS57297
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca