InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sfpi1

Summary

InnateDB Gene

IDBG-190185.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sfpi1

Gene Name

SFFV proviral integration 1

Synonyms

Dis-1; Dis1; PU.1; Sfpi-1; Sfpi1; Spi-1; Tcfpu1; Tfpu.1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000002111

Encoded Proteins

IDBP-190187

SFFV proviral integration 1

IDBP-624596

SFFV proviral integration 1

IDBP-624592

SFFV proviral integration 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20510871

[Homo sapiens] SPI1 (PU.1) directly regulates FLT3 kinase in a concentration-dependent manner, and is a critical regulator of both conventional and plasmacytoid dendritic cell development.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000066336:
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:91082390-91115756

Strand

Forward strand

Band

Transcripts

ENSMUST00000002180	ENSMUSP00000002180
ENSMUST00000131400
ENSMUST00000132741	ENSMUSP00000128457
ENSMUST00000169852	ENSMUSP00000130368

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Experimentally validated
Total	100 [view]
Protein-Protein	46 [view]
Protein-DNA	53 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001085	RNA polymerase II transcription factor binding
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0051525	NFAT protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001944	vasculature development
GO:0002320	lymphoid progenitor cell differentiation
GO:0002573	myeloid leukocyte differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0030098	lymphocyte differentiation
GO:0030218	erythrocyte differentiation
GO:0030225	macrophage differentiation
GO:0030851	granulocyte differentiation
GO:0035019	somatic stem cell maintenance
GO:0043011	myeloid dendritic cell differentiation
GO:0043966	histone H3 acetylation
GO:0044027	hypermethylation of CpG island
GO:0045347	negative regulation of MHC class II biosynthetic process
GO:0045646	regulation of erythrocyte differentiation
GO:0045814	negative regulation of gene expression, epigenetic
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060033	anatomical structure regression
GO:0090241	negative regulation of histone H4 acetylation
GO:1902262	apoptotic process involved in patterning of blood vessels