Version 5.4
Mus musculus Gene: Mybpc3
Summary
InnateDB Gene IDBG-190220.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mybpc3
Gene Name myosin binding protein C, cardiac
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000002100
Encoded Proteins
IDBP-258124
myosin binding protein C, cardiac
IDBP-533930
myosin binding protein C, cardiac
IDBP-624671
myosin binding protein C, cardiac
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134571:
MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:91118144-91136516
Strand Forward strand
Band E1
Transcripts
ENSMUST00000111430 ENSMUSP00000107058
ENSMUST00000137942 ENSMUSP00000119994
ENSMUST00000169776 ENSMUSP00000127070
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0008307 structural constituent of muscle
GO:0017022 myosin binding
GO:0032036 myosin heavy chain binding
GO:0042802 identical protein binding
Biological Process
GO:0002027 regulation of heart rate
GO:0003007 heart morphogenesis
GO:0006936 muscle contraction
GO:0006942 regulation of striated muscle contraction
GO:0008016 regulation of heart contraction
GO:0031034 myosin filament assembly
GO:0045214 sarcomere organization
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005856 cytoskeleton
GO:0005863 striated muscle myosin thick filament
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0031672 A band
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134571
View Gene Order
ENSBTAG00000021707
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_16969
Striated Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.10728
RefSeq NM_008653 XM_006498882
OMIM
CCDS CCDS50631
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca