Version 5.4
Mus musculus Gene: C4bp
Summary
InnateDB Gene IDBG-190275.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C4bp
Gene Name complement component 4 binding protein
Synonyms AI195242; C4bpa
Species Mus musculus
Ensembl Gene ENSMUSG00000026405
Encoded Proteins
IDBP-190277
complement component 4 binding protein
IDBP-535748
complement component 4 binding protein
IDBP-626063
complement component 4 binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21283780
C4bp plays an inhibitory role in antimicrobial response by delaying the classical complement activation and attenuating the lectin pathway activation. The major inhibitory role of C4bp is to facilitate the decay of C3 convertase.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:130634773-130661632
Strand Reverse strand
Band E4
Transcripts
ENSMUST00000027657 ENSMUSP00000027657
ENSMUST00000137276 ENSMUSP00000121185
ENSMUST00000171642 ENSMUSP00000130533
ENSMUST00000190624
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006958 complement activation, classical pathway
GO:0045087 innate immune response (InnateDB)
GO:0045732 positive regulation of protein catabolic process
GO:0045959 negative regulation of complement activation, classical pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0044216 other organism cell
GO:0072562 blood microparticle
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
mmu04610
Complement and coagulation cascades pathway
INOH
PID NCI
Cross-References
SwissProt P08607
TrEMBL E9PUZ8
UniProt Splice Variant
Entrez Gene 12269
UniGene Mm.306720
RefSeq NM_007576
OMIM
CCDS CCDS35700
HPRD
IMGT
MGI ID MGI:88229
MGI Symbol C4bp
EMBL AC109283 AC139231 AK149468 AK149477 BC012257 CH466520 M17122
GenPept AAA37312 AAH12257 BAE28899 BAE28904 EDL39738
RNA Seq Atlas 12269

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca