InnateDB Protein
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IDBP-190277.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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C4bp
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Protein Name
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complement component 4 binding protein
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Synonyms
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AI195242; C4bpa;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000027657
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InnateDB Gene
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IDBG-190275 (C4bp)
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Protein Structure
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Function |
Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006958
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complement activation, classical pathway
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GO:0045087
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innate immune response (InnateDB)
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GO:0045732
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positive regulation of protein catabolic process
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GO:0045959
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negative regulation of complement activation, classical pathway
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Cellular Component |
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PDB ID |
MGI:88229
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InterPro |
IPR000436
Sushi/SCR/CCP
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PFAM |
PF00084
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PRINTS |
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PIRSF |
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SMART |
SM00032
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TIGRFAMs |
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Modification |
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SwissProt |
P08607
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PhosphoSite |
PhosphoSite-P08607
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TrEMBL |
E9PUZ8
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UniProt Splice Variant |
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Entrez Gene |
12269
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UniGene |
Mm.306720
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RefSeq |
NP_031602
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MGI ID |
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MGI Symbol |
C4bp
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OMIM |
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CCDS |
CCDS35700
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HPRD |
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IMGT |
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EMBL |
AC109283
AC139231
AK149468
AK149477
BC012257
CH466520
M17122
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GenPept |
AAA37312
AAH12257
BAE28899
BAE28904
EDL39738
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