Version 5.4
Mus musculus Gene: Rftn1
Summary
InnateDB Gene IDBG-190364.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rftn1
Gene Name raftlin lipid raft linker 1
Synonyms 2310015N21Rik; AI853526
Species Mus musculus
Ensembl Gene ENSMUSG00000039316
Encoded Proteins
IDBP-190366
raftlin lipid raft linker 1
IDBP-254386
raftlin lipid raft linker 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21266579
Rftn1 cooperates with the uptake receptor to mediate cell entry of poly(I:C), which is critical for activation of Tlr3 and the subsequent production of IFN and inflammatory cytokines.
InnateDB Annotation from Orthologs
Summary
PMID 21266579
[Homo sapiens] RFTN1 cooperates with the uptake receptor to mediate cell entry of poly(I:C), which is critical for activation of TLR3 and the subsequent production of IFN and inflammatory cytokines.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131378:
Gene Information
Type Protein coding
Genomic Location Chromosome 17:49992257-50190674
Strand Reverse strand
Band C
Transcripts
ENSMUST00000044503 ENSMUSP00000046524
ENSMUST00000113195 ENSMUSP00000108820
ENSMUST00000156094
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003725 double-stranded RNA binding
Biological Process
GO:0001765 membrane raft assembly
GO:0002457 T cell antigen processing and presentation
GO:0032596 protein transport into membrane raft
GO:0032620 interleukin-17 production
GO:0033227 dsRNA transport
GO:0034138 toll-like receptor 3 signaling pathway
GO:0040007 growth
GO:0043330 response to exogenous dsRNA
GO:0045087 innate immune response (InnateDB)
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:1903044 protein localization to membrane raft
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0043234 protein complex
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000131378
View Gene Order
Cross-References
SwissProt
TrEMBL D3Z731
UniProt Splice Variant
Entrez Gene 76438
UniGene Mm.41854
RefSeq NM_181397
OMIM
CCDS CCDS28873
HPRD
IMGT
MGI ID MGI:1923688
MGI Symbol Rftn1
EMBL AC132235 AC133946
GenPept
RNA Seq Atlas 76438

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca