InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rftn1

Summary

InnateDB Protein

IDBP-190366.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rftn1

Protein Name

raftlin lipid raft linker 1

Synonyms

2310015N21Rik; AI853526;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046524

InnateDB Gene

IDBG-190364 (Rftn1)

Protein Structure

UniProt Annotation

Function

May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen receptor- mediated signaling.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Associates with lipid rafts. {ECO:0000250}.

Disease Associations

Tissue Specificity

Specifically expressed by lymphocytes. {ECO:0000269PubMed:12805216}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding

Biological Process

GO:0001765	membrane raft assembly
GO:0002457	T cell antigen processing and presentation
GO:0032596	protein transport into membrane raft
GO:0032620	interleukin-17 production
GO:0033227	dsRNA transport
GO:0034138	toll-like receptor 3 signaling pathway
GO:0040007	growth
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response (InnateDB)
GO:0050852	T cell receptor signaling pathway
GO:0050853	B cell receptor signaling pathway
GO:1903044	protein localization to membrane raft

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome