Version 5.4
Homo sapiens Gene: LRG1
Summary
InnateDB Gene IDBG-19050.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRG1
Gene Name leucine-rich alpha-2-glycoprotein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000171236
Encoded Proteins
IDBP-19054
leucine-rich alpha-2-glycoprotein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:4536409-4540474
Strand Reverse strand
Band p13.3
Transcripts
ENST00000306390 ENSP00000302621
ENST00000586883
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005160 transforming growth factor beta receptor binding
GO:0005515 protein binding
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0008150 biological_process
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0050873 brown fat cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037095
View Gene Order
ENSBTAG00000031647
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655559
RefSeq NM_052972
HUGO
OMIM
CCDS CCDS12130
HPRD 10056
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca