Version 5.4
Homo sapiens Protein: LRG1
Summary
InnateDB Protein IDBP-19054.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRG1
Protein Name leucine-rich alpha-2-glycoprotein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000302621
InnateDB Gene IDBG-19050 (LRG1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005160 transforming growth factor beta receptor binding
GO:0005515 protein binding
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0008150 biological_process
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0050873 brown fat cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
PFAM PF01463
PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART SM00082
SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P02750
PhosphoSite PhosphoSite-
TrEMBL B4E1I8
UniProt Splice Variant
Entrez Gene 116844
UniGene Hs.655559
RefSeq NP_443204
HUGO HGNC:29480
OMIM 611289
CCDS CCDS12130
HPRD 10056
IMGT
EMBL AF403428 AK303861 BC034389 BC070198
GenPept AAH34389 AAH70198 AAK95527 BAG64800

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca