InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Terf2

Summary

InnateDB Gene

IDBG-190548.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Terf2

Gene Name

telomeric repeat binding factor 2

Synonyms

TRF2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031921

Encoded Proteins

IDBP-190550

telomeric repeat binding factor 2

IDBP-190554

telomeric repeat binding factor 2

IDBP-274159

telomeric repeat binding factor 2

IDBP-533808

telomeric repeat binding factor 2

IDBP-540205

telomeric repeat binding factor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132604:
This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:107069400-107096547

Strand

Reverse strand

Band

Transcripts

ENSMUST00000068421	ENSMUSP00000068948
ENSMUST00000068388	ENSMUSP00000065586
ENSMUST00000116425	ENSMUSP00000112126
ENSMUST00000133925	ENSMUSP00000118759
ENSMUST00000142616	ENSMUSP00000118589
ENSMUST00000141205
ENSMUST00000155834
ENSMUST00000136178

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 233 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	233 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003691	double-stranded telomeric DNA binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0042162	telomeric DNA binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000723	telomere maintenance
GO:0001701	in utero embryonic development
GO:0007049	cell cycle
GO:0010834	telomere maintenance via telomere shortening
GO:0016233	telomere capping
GO:0031627	telomeric loop formation
GO:0031848	protection from non-homologous end joining at telomere
GO:0032205	negative regulation of telomere maintenance
GO:0032206	positive regulation of telomere maintenance
GO:0070198	protein localization to chromosome, telomeric region

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000783	nuclear telomere cap complex
GO:0000784	nuclear chromosome, telomeric region
GO:0001673	male germ cell nucleus
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0030870	Mre11 complex