InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Terf2

Summary

InnateDB Protein

IDBP-533808.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Terf2

Protein Name

telomeric repeat binding factor 2

Synonyms

TRF2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118759

InnateDB Gene

IDBG-190548 (Terf2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 233 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	233 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0042162	telomeric DNA binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000723	telomere maintenance
GO:0001701	in utero embryonic development
GO:0010834	telomere maintenance via telomere shortening
GO:0016233	telomere capping
GO:0031627	telomeric loop formation
GO:0031848	protection from non-homologous end joining at telomere
GO:0032205	negative regulation of telomere maintenance
GO:0032206	positive regulation of telomere maintenance
GO:0070198	protein localization to chromosome, telomeric region

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000783	nuclear telomere cap complex
GO:0000784	nuclear chromosome, telomeric region
GO:0001673	male germ cell nucleus
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0030870	Mre11 complex

Protein Structure and Domains

PDB ID

MGI:1195972

InterPro

IPR001005 SANT/Myb domain
IPR009057 Homeodomain-like
IPR013867 Telomere repeat-binding factor, dimerisation domain
IPR017357 Telomeric repeat-binding factor 1/2
IPR017877 Myb-like domain

PFAM

PF00249
PF08558

PRINTS

PIRSF

PIRSF038016

SMART

SM00717

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt