InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Il24

Summary

InnateDB Gene

IDBG-190579.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il24

Gene Name

interleukin 24

Synonyms

FISP; Mda-7; Mda7; St16

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026420

Encoded Proteins

IDBP-400544

interleukin 24

IDBP-790298

interleukin 24

IDBP-790299

interleukin 24

IDBP-790300

interleukin 24

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162892:
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:130882074-130887454

Strand

Reverse strand

Band

Transcripts

ENSMUST00000121040	ENSMUSP00000113064
ENSMUST00000187650	ENSMUSP00000140149
ENSMUST00000191279	ENSMUSP00000140821
ENSMUST00000188148	ENSMUSP00000139907

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding

Biological Process

GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0030336	negative regulation of cell migration
GO:0033136	serine phosphorylation of STAT3 protein
GO:0042060	wound healing
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0071222	cellular response to lipopolysaccharide
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000162892

View Gene Order

ENSBTAG00000007851

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04060

Cytokine-cytokine receptor interaction pathway

mmu04630

Jak-STAT signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04630

Jak-STAT signaling pathway pathway

INOH

PID NCI

il23pathway

IL23-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

93672

UniGene

RefSeq

NM_053095 XM_006529962

OMIM

CCDS

CCDS15262

HPRD

IMGT

MGI ID

MGI:2135548

MGI Symbol

Il24

EMBL

GenPept

RNA Seq Atlas

93672