Version 5.4
Mus musculus Protein: Il24
Summary
InnateDB Protein IDBP-400544.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il24
Protein Name interleukin 24
Synonyms FISP; Mda-7; Mda7; St16;
Species Mus musculus
Ensembl Protein ENSMUSP00000113064
InnateDB Gene IDBG-190579 (Il24)
Protein Structure
UniProt Annotation
Function Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation. {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Selectively expressed by Th2 cells. {ECO:0000269PubMed:11342597}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
Biological Process
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0030336 negative regulation of cell migration
GO:0033136 serine phosphorylation of STAT3 protein
GO:0042060 wound healing
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071353 cellular response to interleukin-4
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
Protein Structure and Domains
PDB ID MGI:2135548
InterPro IPR009079 Four-helical cytokine-like, core
IPR020443 Interleukin-10/19/20/24/26 family
IPR020444 Interleukin-24
PFAM PF00726
PRINTS PR01937
PIRSF
SMART SM00188
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q925S4
PhosphoSite PhosphoSite-Q925S4
TrEMBL
UniProt Splice Variant
Entrez Gene 93672
UniGene
RefSeq NP_444325
MGI ID
MGI Symbol Il24
OMIM
CCDS CCDS15262
HPRD
IMGT
EMBL AF235006 AF333251
GenPept AAK52470 AAK52590

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca